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Unilateral and Bilateral Deafness

Taken from: https://www.ncbi.nlm.nih.gov/pubmed/17186850

J Vet Intern Med. 2006 Nov-Dec;20(6):1355-62.Prevalence of unilateral and bilateral deafness in border collies and association with phenotype.

Platt S1, Freeman J, di Stefani A, Wieczorek L, Henley W.Author information

Abstract
BACKGROUND:Congenital sensorineural deafness (CSD) occurs in Border Collies, but its prevalence and inheritance are unknown. This study estimated the prevalence of CSD in Border Collies and investigated its association with phenotypic attributes linked to the merle gene, including coat pigmentation and iris color.
HYPOTHESIS:Deafness in Border Collies is associated with pigmentation patterns linked to the merle gene.
ANIMALS:A total of 2597 Border Collies from the United Kingdom.
METHODS:A retrospective study of Border Collies tested, during 1994-2002, by using brainstem auditory evoked responses. Associations between deafness and phenotypic attributes were assessed by using generalized logistic regression.
RESULTS:The prevalence of CSD in puppies was estimated as 2.8%. The corresponding rates of unilateral and bilateral CSD were 2.3 and 0.5%, respectively. Adjustment for clustering of hearing status by litter reduced the overall prevalence estimate to 1.6%. There was no association between CSD and sex (P = .2). Deaf Border Collies had higher rates of merle coat pigmentation, blue iris pigment, and excess white on the head than normal hearing Border Collies (all P < .001). The odds of deafness were increased by a factor of 14 for Border Collies with deaf dams, relative to the odds for dogs with normal dams (P = .007), after adjustment for phenotypic attributes.
CONCLUSIONS AND CLINICAL IMPORTANCE:Associations between CSD and pigmentation patterns linked to the merle gene were demonstrated for Border Collies. Evidence for an inherited component to CSD in Border Collies supports selective breeding from only tested and normal parents to reduce the prevalence of this disease.

PMID: 17186850
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